Wednesday, February 8, 2012

Discovery Predicts Patient Sensitivity to Important Drug Target in ...

Discovery Predicts Patient Sensitivity to Important Drug Target in Deadly Brain Cancer

Study may aid in development of improved therapies for glioblastoma.

Grand Rapids, Mich. (February 6, 2012) ?? A recent discovery by Van Andel Research Institute (VARI) scientists enables the prediction of patient sensitivity to proposed drug therapies for glioblastoma ? the most common and most aggressive malignant brain tumor in humans.

The study, published in January in the Proceedings of the National Academy of Science, investigated glioblastoma models characterized by cell signaling activation and gene amplification for their susceptibility to inhibitors of both the human MET oncogene and the epidermal growth factor receptor (EFGR).

An oncogene is a gene with the potential to cause cancer. In tumor cells, they are often mutated or expressed at high levels. High MET levels often occur in human tumors, and cells with inappropriate MET signaling produce activity that potently affects the spread of cancer. This signaling is implicated in most types of human cancers and high MET expression often correlates with poor prognosis. Mutations affecting EGFR expression or activity are also linked to cancer.

?Because oncogene MET and EGFR inhibitors are in clinical development against several types of cancer, including glioblastoma, it is important to identify predictive markers that indicate patient subgroups suitable for such therapies,? said VARI Research Scientist Qian Xie, Ph.D., lead author of the study.

?Studies have shown that targeting MET signaling can have potent antitumor effects,? said Co-Author George F. Vande Woude, Ph.D., Head of the VARI Laboratory of Molecular Oncology. ?Therefore, it is important to understand the mechanisms leading to HGF/MET sensitivity and to identify the patient subgroups most likely to benefit from MET-targeted therapeutics.?

Dr. Vande Woude?s career can be characterized by the uniquely broad scope of his work with MET and its molecular partner hepatocyte growth factor (HGF) ?from the original cloning and characterization of the gene, through explaining the role of the HGF/ MET signaling pathway in human cancers, and then to applying that knowledge toward the identification of inhibitors of this important cancer pathway. Because MET and HGF play such an integral role in the process of cell survival, growth, blood vessel formation, and metastasis, they are a significant target in the development of anti-cancer drugs.

Dr. Vande Woude is also the co-author of an article published last week in Nature Reviews Cancer entitled ?Targeting MET in cancer: rationale and progress,? which updates the progress of MET and HGF as targets in the development of anti-cancer drugs.

?Progress in understanding this vital process has led to the successful development of blocking antibodies and a large number of small-molecule MET kinase inhibitors,? said Vande Woude. ?Results from recent clinical studies demonstrate that inhibiting MET signaling in several types of solid human tumors has major therapeutic value.?

Papers:

Xie, Q. et al. (2012). Hepatocyte growth factor (HGF) autocrine activation predicts sensitivity to MET inhibition in glioblastoma. Proceedings of the National Academy of Science. 109: 570?575. http://www.pnas.org/content/109/2/570.full?sid=9fd02a21-ddd0-4a1f-8392-35f636affe19

Gherardi, E., Birchmeier, W., Birchmeier, C. & Vande Woude, G. (2012). Targeting MET in cancer: rationale and progress. Nature Reviews Cancer. 12: 89-103. http://www.nature.com/nrc/journal/v12/n2/full/nrc3205.html#top

Contact:?Communications?& Development, VARI, Tel: 616-234-5390

Source: Van Andel Institute

Source: http://insciences.org/article.php?article_id=10671

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Saturday, January 7, 2012

Rapper says 'Black and Yellow' rips off his song

Dave Martin / AP

Wiz Khalifa is being sued over his hit song "Black and Yellow."

By Gael Fashingbauer Cooper

Pittsburgh rapper Maxamillion is suing hip-hopper Wiz Khalifa for $2.3 million, saying Khalifa's hit song, "Black and Yellow," was based on his own song, "Pink N Yellow."

Max Warren, who performs under the name Maxamillion, filed the copyright infringement lawsuit in federal court in Philadelphia, the Assoociated Press is reporting.

He says he copyrighted "Pink N Yellow" in 2008, three years before "Black and Yellow" was copyrighted.

"Black and Yellow" reached No.1 on the Billboard Hot 100, Khalifa's first song to do so. It's been played repeatedly in connection with sporting events, since the colors are the colors of Pittsburgh's sports teams. Numerous other versions have been created naming other team's colors, and comedy site Funny or Die even offers a version, "Black and Jewish," paying tribute to celebrities with mixed ethnic background.

?Listen to the songs below and tell us on Facebook?if you think?Maxamillion has a case against Wiz Khalifa. (Warning: Mature lyrics.)

"Black and Yellow":

"Pink N Yellow":

?Related stories:

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Source: http://entertainment.msnbc.msn.com/_news/2012/01/06/10007010-rapper-says-black-and-yellow-rips-off-his-song

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NBA High-5: Grizzlies' chances to contend suffer big blow in Zach Randolph's knee injury

The five most interesting stories, rumors and notes in the NBA:

1. Big blow for Grizzlies: The language coming out of Memphis yesterday seemed designed to keep Grizzlies fans calm, with such words as precautionary, bruise, relief and dodges a bullet.

But the language surely turned bluer today.

The Grizzlies learned that forward Zach Randolph, their leading scorer and rebounder last season, will miss about eight weeks with a tear in the medial collateral ligament of his right knee, the Memphis Commercial Appeal's Ronald Tillery reports.

Randolph suffered the injury in the first half of Memphis' game against Chicago on Sunday. With Randolph out, the Bulls routed the Grizzlies 104-64.

Eight weeks takes the Grizzlies past the All-Star break, a major blow for a franchise that seemed on the cusp of contending in the Western Conference.

The Grizzlies have already made a move help make up for the loss. Tillery reports that they have agreed to a three-team deal that would land them big man Marresse Speights from the 76ers. Memphis would send guard Xavier Henry to New Orleans, and the Hornets would ship two second-round picks to Philadelphia.

Randolph's injury was initially portrayed as being minor. On Monday, he had an MRI and his agent, Raymond Brothers, told USA Today that the results showed a bone bruise. Sounds innocuous, right? On Tuesday, the Grizzlies had no further updates on the injury, and with another former Blazer, Dante Cunningham, starting in Randolph's place, Memphis handled visiting Sacramento 113-96 to improve to 2-3.

But the bad news came down today. Randolph, Tillery reports, won't need surgery, but you have to wonder about the long-term ramifications. Randolph, remember, had microfracture surgery on the same knee in 2005, when he was with the Blazers.

Randolph, who turned 30 this year, signed a four-year, $71 million extension with Memphis in April.

Memphis has shown an ability to play through injuries, making a strong playoff run last season without forward Rudy Gay, who missed the stretch drive and postseason after shoulder surgery. Gay led Memphis with 23 points and eight rebounds last night.

But with reserve power forward Darrell Arthur out for the season with an Achilles' tendon injury, Memphis is starting to run out of quality big bodies. The extended absence by Randolph figures to put a lot on the shoulders of Cunningham, who, as Blazers fans are aware, should know that feeling well.

2. A King again: From the Sacramento side, Tuesday's game was notable for the return of DeMarcus Cousins, the volatile second-year center who was sent home from the Kings' home game against New Orleans on Sunday after he apparently demanded to be traded.

That was followed by reports about which teams might make a run at him, then by news that Cousins would rejoin the team for its two-game road trip that started last night in Memphis and concludes tonight in Denver.

There also was some bizarre he-said-he-said stuff between Cousins and coach Paul Westphal, as reported by the Sacramento Bee's Jason Jones. Cousins issued a statement in which he claimed he never asked to be traded. Westphal revealed there had been multiple incidents with Cousins, and that the team would provide

"less protection" from incidents becoming public.Jones adds that Cousins played 22 minutes off the bench last night and had four points and eight rebounds and shot 1 for 5 from the field. After the game, Westphal said Cousins handled himself "in a professional way, and that's always a good thing," and Cousins said it "felt weird" to come off the bench.3. Veteran presence: If you want to see the opposite of an immature-but-talented big guy having a negative effect on his team, see the Indiana Pacers.

The Pacers are off to a 4-1 start, and much of the credit goes to veteran power forward David West, who signed with them as a free agent. West is averaging 12.4 points and 7.6 rebounds, and he brings much more in experience and professionalism, Yahoo's Adrian Wojnarowski writes.

West, 31, has been a huge asset for young coach Frank Vogel, who has a young, talented roster to mold.

"He does a lot of one-on-one mentoring, and does it every day," Vogel tells Wojnarowski. "Just his presence ? guys are going to think twice before they handle themselves the wrong way. Big brother is there. He?s a good observer; he knows what the right chemistry feels like. He knows when guys need hugs, when guys need a kick in the butt."

West was pursued hard by Boston, which offered a three-year, $24.5 million deal,? but he chose to take the Pacers' two-year, $20 million offer instead. He explains the choice:

"This was a decision that was thought out. I examined it from top to bottom. People who know me know that I?m not going to just say, ?Well, they offered me more money, so I?m going to sign there.? That?s not how I operate. This group has such good young pieces, I really think this is going to be one of the better teams over the next two years.?

4. Learning from a vet: The Celtics did add a different veteran, and he seems to be having a positive impact on the key player for the Celtics as they start to transition out of the Big Three era.

Point guard Rajon Rondo is in his sixth NBA season and has been in two All-Star Games, but he's not too high and mighty to learn from a player who's been in the league longer.

Comcast Sportsnet Northeast's Jessica Camerato reports that Rondo moved spots in the Celtics' locker room and is now next to veteran point guard Keyon Dooling, who joined the Celtics via a trade from Milwaukee. And while Dooling has never been a star player, he is in his 12th season in the league, and Rondo is using the proximity to pick the veteran's brain.

"I think it?s big because he?s a veteran point guard," Rondo tells Camerato. "He has a lot of great information for me. I can learn a lot from him."

Dooling is a true pro and has things to teach Rondo beyond basketball.
"
"Stuff off the court, family issues, growing and being a businessman -- there?s a lot of different venues and different outlets he?s trying to teach me, which is also a good thing for me," Rondo said.

5. Patty-cakes talk: There was a little burst on Twitter in the last day after Yahoo's Wojnarowski reported via that medium that former Blazers point guard Patty Mills had been released by Xinjiang of the Chinese Basketball Association.

There have been some weird reports that the team accused Mills of faking a hamstring injury, and Mills firing back. But here in Portland, the focus for some has been on: can the Blazers get Mills back?

Mills is a popular guy in Portland, but it seems unlikely the Blazers are in a rush to re-sign him. For one thing, they already have 15 players on their roster and would have to waive someone to get Mills. While center Chris Johnson is only conditionally guaranteed, it's doubtful the Blazers would cut him loose to make room for Mills.

This morning, the Blazers sent second-year players Luke Babbitt and Armon Johnson to their Idaho D-League affiliate, a move predicted by Wendell Maxey in a story for Ridiculousupside.com that also offers good perspective from the Blazers' director of NBA scouting, Michael Born.

You don't do that unless you are comfortable with your roster. Mills does not fill an immediate need for Portland, which needs to be the main motivation for any personnel move at this point in the season. The Blazers already got a point guard rotation in starter Raymond Felton, Jamal Crawford off the bench and an occasional appearance by rookie Nolan Smith, a player the coaches like.

There's also the FIBA hurdle. As Wojnarowski writes, even though Xinjiang released him, Mills' contract binds him to the Chinese Basketball Association until the end of the Chinese season in late February or March.

The NBA generally follows FIBA rulings, so Mills would have to obtain a letter of clearance from basketball's ruling body, something NBA veteran Kenyon Martin -- who also was released by a Chinese team -- has been unable to get.

Sorry, Patty-cakes fans. Does not look likely.

-- Mike Tokito

Source: http://www.oregonlive.com/nba/index.ssf/2012/01/nba_high-5_135.html

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Friday, January 6, 2012

Sony Ericsson has released a second teaser over Facebook ?Just a few more days until we can reveal some interesting news ? what do you want it to be??

It?s CES time! Whoever in electronic industry is excited to come to Vegas and see what?s new at CES (Consumer Electronic Show).

Sony Ericsson, Sony mobile manufacturer, has left a bit of hint on its facebook with a picture.

Sony Ericsson Facebook Tease

The former joint Swedish-Japanese mobile phone maker is rumoured to be launching the codename ?Xperia Nozomi? device at CES, which has been leaked on-line by many different websites, from press images to actual photos and specifications.

Sony Ericsson?s Xperia ?Nozomi? has been rumoured to have the official name of the Xperia HD and this is likely to be confirmed next week.

Adding more weight to that naming speculation is the ?HD? logo on the phone, shown in the lower left image below.

The Xperia HD could obtain its name, according to reports, from housing a HD resolution display ? in the same way as the Samsung Galaxy Nexus ?Ice Cream Sandwich? has, with a 720?1280 screen.

Read more: http://www.itproportal.com/2012/01/05/sony-ericsson-releases-teaser-mobile-phone-picture-facebook-ahead-unveiling-handset-ces-las-vegas/#ixzz1icXvIPoi

Source: http://feedproxy.google.com/~r/GomoNews/~3/WZc72R2yZMY/

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Benedict Cumberbatch Lands Villain Role In 'Star Trek 2'

BBC's 'Sherlock' actor also has upcoming roles in 'The Hobbit.'
By Kevin P. Sullivan, with reporting by Josh Horowitz


Benedict Cumberbatch imagined in the role of Khan
Photo: Getty Images/ MTV News/ Paramount TV

Damon Lindelof, "Lost" co-creator and one of the screenwriters behind J.J. Abrams' "Star Trek 2," tweeted on Monday, "Something really, REALLY cool just happened. #BoldlyGo." All signs pointed to a looming "Trek" announcement, but we didn't find out what was setting Lindelof's phasers to stun until two days later.

Benedict Cumberbatch, the British actor most recently seen in "War Horse" and "Tinker Tailor Soldier Spy," will play the main villain in the "Star Trek" sequel. This was the role for which Abrams originally wanted Benicio Del Toro, but had Édgar Ramirez circling once Del Toro was out of the picture, Variety reported.

There is still no word on what character Cumberbatch will play. When Del Toro led as the front-runner, Internet rumors suggested Khan, the legendary villain originally played by Ricardo Montalbán in "Star Trek II: The Wrath of Khan," would reappear in Abrams' alternate "Trek" universe.

In the past year, Cumberbatch has seen his stateside profile rise significantly. Known primarily in England for his widely beloved role as the modern-day reimagining of Sherlock Holmes in the BBC's "Sherlock," the actor starred alongside Gary Oldman in "Tinker Tailor" and played a minor role in Steven Spielberg's "War Horse." Next year, he'll take on two key roles in Peter Jackson's "The Hobbit," doing the voice and motion capture for Smaug and presumably both for the Necromancer.

Deadline's report on the Cumberbatch casting mentioned that Abrams plans to shoot the film in 3-D, which contradicts what the director told MTV News' Josh Horowitz on the red carpet for "Mission: Impossible - Ghost Protocol." "We're shooting on film, 2-D, and then we'll do a good high-end conversion like the 'Harry Potter' movie and all that," Abrams said. "Luckily, with our release date now, we have the months needed to do it right, because if you rush it, it never looks good."

Check out everything we've got on "Star Trek 2."

For breaking news, celebrity columns, humor and more — updated around the clock — visit MTVMoviesBlog.com.

Related Videos Related Photos

Source: http://www.mtv.com/news/articles/1676776/benedict-cumberbatch-star-trek-2-villain.jhtml

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Thursday, January 5, 2012

Evelyn Lozada and Chad Ochocinco Wedding: Called Off Due to Cheating Allegations!

Chad Ochocinco's fiancee Evelyn Lozada may 86 the couple's wedding for good because she suspects 85 has been cheating behind her back, according to new reports.

The Basketball Wives reality star recently confronted the Chad after she became suspicious about his recent behavior ... and apparently wasn't moved by his reaction.

The couple hasn't split up, but the wedding is off ... for now.

Chad Ochocinco and Evelyn Lozada

Evelyn Lozada and Chad Ochocinco are (were?) set to marry this summer.

While Evelyn hasn't "officially" cancelled the wedding yet, things aren't looking good right now. It's still unclear if this will be resolved in time ... or at all.

To make matters worse, Chad and Evelyn were supposed to begin shooting their new reality show in just three weeks. That plan is also now up in the air.

Lozada was also at the center of cheating allegations recently - with Terrell Owens no less - but this time it's Ocho who's supposedly been running around.

We know you can't take the suspense, but we'll keep you updated. Stay tuned.

[Photo: WENN.com]

Source: http://www.thehollywoodgossip.com/2012/01/evelyn-lozada-and-chad-ochocinco-wedding-called-off-due-to-cheat/

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Defending Snooki ... no, really!

Noel Vasquez / Getty Images Contributor

Nicole "Snooki" Polizzi isn't really so bad.

By Ree Hines

The fifth season of "Jersey Shore" kicks off Jan. 5, and that means it's time for all the usual Seaside Heights fun, including hookups, fights and alcohol-filled parties ? most, if not all, of which will revolve around Nicole "Snooki" Polizzi, otherwise known as the unofficial star of the show.

That also means many viewers and even more non-viewers will resume their seasonal pastime of Snooki-bashing, which seems to involve criticizing the Princess of Poughkeepsie for almost every mundane move and outrageous act that she makes.

But why?

OK, sure. She can't hold her liquor, as evidenced by her boozy beach arrest in season three, repeated "kooka" flashings and nearly every fight she's ever had with her boyfriend, Jionni. And, yes, she's used the house minifridge to cool her itchy backside alongside the Cheez-its and Red Bull when a new tanning cream left her a little rashy. And it's true that even outside of "Shore" she's given dieting advice that's included drinking vodka and recommended kitty litter as a beauty product. But then again, aren't some of these things what make Snooki so great?

Great? Yeah, great. Well, not the public drunkenness maybe, but the general over-the-top behavior is part of?what makes Snooki worth watching. She's like a cartoon character come to life, ready to do and say what most others won't and probably shouldn't. It's part of her appeal, and it's part of why she's worth defending against her many detractors.

Besides, Snooki's appeal goes far beyond her diminutive, do-anything routine. Those who look past some of her embarrassing habits might just notice her winning qualities, such as the fact she's a loyal friend to the women in her life (minus the occasional Sammi mess and that whole thing with Angelina, but hey, they had it coming) and she won't let anyone tear her down.

The latter might just make up her best quality. See, despite all the requisite bashing, for the most part, Snooki takes it in stride. She doesn't get overly mad or offended. She refuses to be shamed for her behavior. And if a swipe is crafted with a sense of humor, she even seems to appreciate it. ??

If there's a Snooki-related joke to be made, she's either making it or she's among those laughing the loudest.

Heck, when Bobby Moynihan repeatedly poked fun?at her on "Saturday Night Live," she didn't simply approve of the send-up. She teamed up with him for some dueling-Snookis action on MTV.

And when South Park portrayed the "Shore" star as a rusty colored, hunched-back, whiskered beast who creeped around in constant pursuit of "smoosh-smoosh," she took it as a sign of her success.

"Snooki want smoosh smoosh," she tweetedthe night the episode aired. "I'm going to have nightmares tonight. lmao!!! We've officially made it. Goodnite my b----es ?"

That's an indomitable spirit, and it's all too rare in real life or reality TV.

See the latest from Snooki and the rest of the Seaside Heights gang when "Jersey Shore" returns to MTV Thursday, Jan. 5., at 10 p.m.

What do you think is the dumbest/funniest thing Snooki has ever done? Sound off on our Facebook page.

Is she worth defending?

?

Related content:

Source: http://theclicker.today.msnbc.msn.com/_news/2012/01/03/9927771-defending-snooki-no-really

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